Human Brain Project


HBP logo 2017


    HBP Official site



The HBP Flagship was launched by the European Commission’s Future and Emerging Technologies (FET) scheme in October 2013.

The HBP has the following main objectives:

  • Create and operate a European scientific Research Infrastructure for brain research, cognitive neuroscience, and other brain-inspired sciences
  • Gather, organise and disseminate data describing the brain and its diseases
  • Simulate the brain
  • Build multi-scale scaffold theory and models for the brain
  • Develop brain-inspired computing, data analytics and robotics
  • Ensure that the HBP’s work is undertaken responsibly and that it benefits society.

The timeline of the Project is split into multiple phases, each of which will be covered by a separate funding agreement, the Ramp-Up Phase (October 2013 to March 2016), the Specific Grant Agreement One (SGA1), that is the current phase (April 2016–April 2018) and the next phase (SGA2). The FET Flagships Staff Working Document provides further information on how Flagships are funded.  

28 January 2013: The European Commission has announced that the Human Brain Project (HBP) is the winner of the FET (Future and Emerging Technologies) call.

HBP faces an extraordinary challenge for modern sciences: to integrate available knowledge on the human brain in order to reconstitute its functioning in computo and in silico through advanced informatics platforms.

The goal is to understand brain functioning inner mechanisms, to find new cures for brain diseases, and to generate intelligent computers and robots.

More than 80 Research Centers participate at the Human Brain Project.



Prof. Egidio D’Angelo is the Principal Investigator of the Pavia HBP-Unit.

The HBP-Italian Unitsparticipating are the following (click on the map to enlarge):

HBP Italian Units map

  • Egidio D’Angelo (University of Pavia)
  • Giovanni Erbacci (CINECA -Bologna)
  • Giovanni Frisoni (FBF – Brescia)
  • Enrico Macii (Politecnico di Torino)
  • Francesco Pavone (LENS, University of Florence)
  • Antonino Cattaneo (Scuola Normale Superiore di Pisa)
  • Enrico Cherubini (European Brain Research Institute Rita Levi-Montalcini Fondazione – EBRI – Roma)
  • Michele Migliore (Consiglio Nazionale delle Ricerche – Palermo)
  • Cecilia Laschi (Scuola Superiore di Studi Universitari e di Perfezionamento – Pisa)



26-28 Jan 2015: HBP Board of Directors meeting – Bruxelles

16-17 Jan 2015: HBP Preliminary Findings – Frankfurt

28 Sep-4 Oct 2014: HBP Summit- Heidelberg



The main themes of the Human Brain Project (HBP) have been illustrated in a special issue (n. 3 2013) of Functional Neurology published to coincide with the joint HBP – OTTORINO ROSSI AWARD meeting, 17-18 October 2013 (Pavia, Italy). 

  • ITALIAN PRESS on Human Brain Project.
  • The Human Brain Project, the Italian Contribution – VIDEO

– – –

– – –



Publications with HBP grant


  • E. D’Angelo; P. Mazzarello. MRI observation of hippocampal degeneration in Alzheimer’s disease: A forgotten case. Functional Neurology Volume 28, Issue 3, July 2013, Pages 245-246.
  • E. D’Angelo, S. Solinas, J. Garrido, C. Casellato, A. Pedrocchi, J. Mapelli, D. Gandolfi, F. Prestori. Realistic modeling of neurons and networks: towards brain simulation. Functional Neurology 2013; 28(3): 153-166.


  • L. Mapelli, S. Solinas, E.D’Angelo. “Integration and regulation of glomerular inhibition in the cerebellar granular layer circuit”. Frontiers in Cellular Neuroscience.
  • D. Gandolfi, P. Pozzi, M. Tognolina, G. Chirico, J. Mapelli and E. D‘Angelo. “The spatiotemporal organization of cerebellar network activity resolved by two-photon imaging of multiple single neurons”. Frontiers in Cellular Neuroscience (2014).
  • E. D’Angelo. The organization of plasticity in the cerebellar cortex: from synapses to control. Prog Brain Res. 2014;210:31-58. doi: 10.1016/B978-0-444-63356-9.00002-9.
  • G. Castellazzi, F. Palesi, S. Casali, P. Vitali, E. Sinforiani, C.A.M. Wheeler-Kingshott, E. D’Angelo. A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia. 30 Jul 2014. Front. Neurosci. doi: 10.3389/fnins.2014.00223. 
  • F. Palesi, D. J. Tournier, F. Calamante, N. Muhlert, G. Castellazzi, D. Chard, E. D’Angelo, C.A.M. Wheeler-Kingshott. Controlateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in human in-vivo. Brain Structure and Function.  2014 Aug 19. 
  • Monaco J., Casellato C., Koch G., D’Angelo E. Cerebellar theta burst stimulation dissociates memory components in eyeblink classical conditioning. European Journal of Neuroscience, Sep. 2014, DOI: 10.1111/ejn.12700.
  • S. Subramaniyam, S. Solinas, P. Perin, F. Locatelli, S. Masetto, E. D’Angelo. Computational modeling predicts the ionic mechanism of late-onset responses in Unipolar Brush Cells. Frontiers in Cellular Neuroscience. Front. Cell. Neurosci., 20 August 2014. doi:10.3389/fncel.2014.00237. 
  • T.R. Nieus, L. Mapelli, E. D’Angelo. Regulation of output spike patterns by phasic inhibition in cerebellar granule cells. Front. Cell. Neurosci., 25 August 2014 | doi: 10.3389/fncel.2014.00246.
  • C. Casellato, A. Antonietti, J. A. Garrido, R.R. Carrillo, N.R. Luque, E. Ros, A. Pedrocchi, E. D’Angelo. Adaptive Robotic Control Driven by a Versatile Spiking Cerebellar Network. PlosOne 2014 Nov 12;9(11):e112265. doi: 10.1371/journal.pone.0112265. eCollection 2014.
  • 2016

Leave a Reply

Your email address will not be published. Required fields are marked *