The research acitivity of the Laboratory of Prof. D’Angelo covers the study of the cerebellum both at cellular and molecular levels and on network organization. The main interest is the understanding of the properties involved in synaptic learning processes, such as synaptic transmission, the ionic bases of the neural code, the spatio-temporal organization of signal encoding and cellular neuropathology.
The models and tools used to study the whole network are several: electrophysiological experiments and imaging of cerebellar tissue slices or in-vivo; complex mathematical simulations (using platforms: Python, Matlab, Neuron); developing research protocols to be applied to Transcranial Magnetic Stimulation (TMS) and functional Magnetic Resonance Imaging (fMRI), related to the cerebellum and ufseful for the care treatment of diseases such as: ataxia, dyslexia, autism, schizophrenia and depression.
Research activity is made in 2 buildings located respectively in University of Pavia and in IRCSS Mondino Foundation with the following techniques:
1. LABORATORY OF NEUROPHYSIOLOGY (Team)
(Dep. of Brain and Behavioral Sciences, Unit of Neurophysiology, Via Forlanini, 6 – University of PAVIA)
- IN-VIVO Recording
2. LABORATORIES OF TMS and MRI (Team)
(IRCCS C. Mondino Foundation – Via Mondino, 2 – PAVIA)
- TRANSCRANIAL MAGNETIC STIMULATION (TMS)
(Experiments made with MagStim Stimulator)
- Colnaghi S., Ramat S., D’Angelo E., Versino M. (2010). Transcranial magnetic stimulation over the cerebellum and eye movements: state of the art. Functional Neurology 2010; 25(3): 165-171.
- Colnaghi S, Ramat S, D’Angelo E, Cortese A, Beltrami G, Moglia A, Versino M. (2011). Theta-burst stimulation of the cerebellum interferes with internal representations of sensory-motor information related to eye movements in humans. Cerebellum. 2011 Dec;10(4):711-9.
- Monaco J., Casellato C., Koch G., D’Angelo E. (2014). Cerebellar theta burst stimulation dissociates memory components in eyeblink classical conditioning. European Journal of Neuroscience, Sep. 2014, DOI: 10.1111/ejn.12700.
- FUNCTIONAL MAGNETIC RESONANCE IMAGING (fMRI)
E. D’Angelo; P. Mazzarello. (2013). MRI observation of hippocampal degeneration in Alzheimer’s disease: A forgotten case. Functional Neurology Volume 28, Issue 3, July 2013, Pages 245-246.
- F. Di Lorenzo, A. Martorana, V. Ponzo, S.Bonnì, E. D’Angelo, C. Caltagirone and G.Koch. (2013). Cerebellar theta burst stimulation modulates short latency afferent inhibition in Alzheimer’s disease patients. Frontiers in Aging Neuroscience. Vol. 5, article 2, February 2013.
- G. Castellazzi, F. Palesi, S. Casali, P. Vitali, E. Sinforiani, C.A.M. Wheeler-Kingshott, E. D’Angelo (2014). A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia. Front. Neurosci., 30 July 2014. doi: 10.3389/fnins.2014.00223.
- F. Palesi, D. J. Tournier, F. Calamante, N. Muhlert, G. Castellazzi, D. Chard, E. d’Angelo, C.A.M. Wheeler-Kingshott (2014). Controlateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in human in-vivo. Brain Structure and Function. 2014 Aug 19.
- Other techniques used: Diffusion Tensor Imaging (DTI); Electroencephalography (EEG); Electromyographic (EMG) recordings; Brain Computer Interface (BCI)