2020 News:

We are glad to announce a new publication on Nature Communications Biology from the team of the Neurophysiology Laboratory directed by Prof. Egidio D’Angelo (through a collaboration of scientists of the Department of Brain and Behavioral Science 1, Molecular Medicine 2, and Biology and Biotechnology 3 of the University of Pavia) that has revealed a new unanticipated property of cerebellar granule cells.

Masoli, S.1, Tognolina, M.1, Laforenza, U.2, Moccia F.3, D’Angelo E.1 Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage. Commun Biol 3, 222 (2020). https://doi.org/10.1038/s42003-020-0953-x

Follow the linked picture to dowload the pdf file

Cellular-resolution mapping uncovers spatial adaptive filtering at the cerebellum input stage
Casali Stefano, Tognolina Marialuisa, D’Angelo Egidio
doi: https://doi.org/10.1101/2020.03.14.991794

avaialable on Biorxiv

Congratulation to Alice Geminini for the interview entitled

“A virtual brain to create new treatments”

published on “La Stampa” in occasion of the “International Women’s day”

We are glad to invite you at the seminar entitled:

“Is seeing believing? – Building a model system

to study predictive coding in the cortex”

Prof. Ede Rancz

Cortical Circuits Laboratory
The Francis Crick Institute
London, England

Friday, 21 February 2020
h 14:30
Aula A, sec. of Human Physiology
Via Forlanini 6

UniPV su «National Geographic» alla scoperta del cervello

Hackathon on cerebellum modelling

3-15 January 2020

The Hackathon on CEREBELLUM MODELLING will illustrate cerebellum models and provide tutorials for their development and applications. The course is designed with selected presentations and large space for hands-on experience. The attendees will be introduced to the main  themes of cerebellum modelling and to the use of the HUMAN BRAIN PROJECT research infrastructure, Brain Simulation Platform and future EBRAINS, addressing the principles of multiscale brain modeling.

In this Hackathon, the attendees will elaborate and simulate computational models of neurons and networks of the cerebellum. Topics will include:

    • an illustration of the Brain Simulation Platform models and use cases and of the related modeling languages (PYTHON, NEURON, NEST, PYNN, SONATA, ARBOR)
    • the foundations of realistic data-driven neuronal modeling, including biophysical principles, model matching to experimental data (optimization), supervised model simplification.
    • the foundations of realistic data-driven microcircuit modeling, especially cell placement and connectivity in microcircuit scaffolds
  • the scale-up to large-scale and brain models and their incorporation in robots, neuromorphic hardware and virtual brain. 

Organized by Neurocomputation Laboratory, Dept. of Brain and Behavioral Sciences, University of Pavia

Via Forlanini 6 – 27100 – Pavia, Italy

The participation of researchers and students is recommended, with particular reference to those involved in modeling and computational studies and attending to PhD programs.

Streaming, tutorials, virtual machine and pictures of the event are available at this link

Hackathon website

IDCD (http://idcd.unipv.it/streaming-hackathon/)

Progetto in collaborazione con Centro Fermi

Microcircuiti Neuronali Locali (MNL) 

Tecniche Avanzate per Applicazioni Biomediche


Il Progetto Microcircuiti Neuronali Locali (MNL) si occupa della comprensione della organizzazione e delle funzioni del cervello (Figura 11). La complessità del cervello dipende dal modo in cui i neuroni interagiscono e comunicano a livello delle sinapsi. I neuroni sono circa 1000 miliardi e le sinapsi un milione di miliardi e generano in tempo reale funzioni complesse come il movimento, la percezione e il pensiero. Il Progetto MNL, inserito nell’Human Brain Project europeo, cerca di impiegare modelli matematici sofisticati per ricostruire la funzione neuronale, circuitale e cerebrale. Nel prossimo triennio si propone tre obiettivi principali: i) completare il campione di misure in corso per aumentarne la potenza statistica; ii) esplorare i meccanismi di non linearità dell’accoppiamento neuro-vasoclare; iii) comparare il comportamento della corteccia cerebellare con quello della corteccia cerebrale, sulla base delle sue proprietà molecolari e microstrutturali.

2019 News:

We are pleased to send this invitation round

Dear all,

The Chicago chapter of the international association of Italian scientists (AIRIcerca) would like to invite you to its social event that will take place during the upcoming conference Neuroscience 2019! We will get together on Sunday October 20th at 8.00pm at the Emporium – Fulton Market (839 W Fulton Market-Chicago, https://emporiumchicago.com/location/fulton-market/) for a night of arcade games, music and drinks. The event flier is attached to this email.

Please RSVP using this link: https://forms.gle/GZ8UW8AiFY6JbB4e8

The bar is easily reachable by train (green line, Morgan stop) from the conference venue, https://goo.gl/maps/jWwvZqn5bXHMoQWF7
You will need a picture ID (passport or driver’s license) to access the bar.

We look forward to meeting you all!

Board AIRIcerca Chicago Chapter

Cristiano Alessandro,
Anadi Canepa,
Lorenza Culotta,
Dalia De Santis,
Francesca Foggetti,
Eleonora Forte,
Alessandra La Rosa,
Marco Mambelli,
Christian Marinaccio
Roberto Ponciroli

Newsletter of the University of Pavia

L’Università di Pavia al centro del sistema europeo di modellizzazione del cervello

The wonder of Human Brain; 40° Rimini Meeting, 18-24 August 2019 STREAM

We are glad to invite you at the seminar entitled:

Prof. Carlo Pierpaoli

Quantitative Medical Imaging
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
 National Institute of Health (NIH)

Monday 30 September 2019, h 14:00

Aula Volta

Corso Strada Nuova


Brief Bio:

Dr. Pierpaoli’s is an Investigator in the Quantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH. Research in his lab is aimed at extracting accurate and reproducible biomarkers from data acquired with non-invasive imaging techniques, primarily Magnetic Resonance Imaging (MRI). Dr. Pierpaoli is mainly known for his contributions in the field of diffusion MRI applied to brain studies. He is a fellow of the International Society of Magnetic Resonance and received the NIH Award of Merit for performing the first diffusion tensor imaging study of the human brain.


Tensor‐based morphometry (TBM) performed using T1‐weighted images (T1WIs) is a well‐established method for analyzing local morphological changes occurring in the brain due to normal aging and disease. However, in white matter regions that appear homogeneous on T1WIs, T1W‐TBM may be inadequate for detecting changes that affect specific pathways. In these regions, diffusion tensor MRI (DTI) can identify white matter pathways on the basis of their different anisotropy and orientation. In the last couple of years, our lab has investigated the possibility of performing TBM using deformation fields constructed using all scalar and directional information provided by the diffusion tensor (DTBM) with the goal of increasing sensitivity in detecting morphological abnormalities of specific white matter pathways.

In this talk I will present results that indicate that DTBM could be a powerful tool for detecting morphological changes of specific white matter pathways in normal brain development and neurological disorders.

July 10, 2019

14.00, Aula Alario, Politecnico di Milano, Via Golgi 39, Building 21, 2nd floor

Prof. Michele Giuliano

Neuroscience Sector, International School of Advanced Studies (SISSA), Trieste – Italy

Department of Biomedical Sciences, University of Antwerp, Belgium

Correlation transfer in cortical neurons

Scientific area: Technologies

Contacts: Raffaele Dellacà raffaele.dellaca@polimi.it


More information are available at our PhD website https://www.phdbioengineering.polimi.it/?m=7&id=1 .

School of Brain Cells & Circuits

“Camillo Golgi”

Ettore Majorana Foundation and Centre for Scientific Culture, Erice (Italy)

Modeling the brain and its pathologies

Course Directors: Egidio D’Angelo, Claudia Gandini Wheeler-Kingshott & Viktor Jirsa

Date: 27th August – 1st September 2019

Abstract submission is now open.

Casella Prize 2019 awarded  to Idan Segev


The Casella Prize 2019 is awarded to Prof. Idan Segev for his outstanding scientific activity in neuroscience, with specific regard to brain modeling. Especially relevant are the results, published in top-rank international journals, on the biophysical and mathematical structure of neuronal and microcircuit functions of the cerebral cortex in mouse and humans. These results open important scenarios for future neuroscientific studies and suggest potential applications in the biomedical sector.

The video of the talk can be found at this link: Brain in the computer: what did I learn from simulating the brain

The Brain Simulation platform just tweeted:

CASELLA PRIZE, 22 May 2019

L E C T I O     M A G I S T R A L I S



Brain in the computer:

what did I learn from simulating the brain

Prof. Idan Segev


Department of Neurobiology and the Edmond and Lily Safra Center for Brain Sciences Hebrew University of Jerusalem

Jerusalem, Israel

Almo Collegio Borromeo | Piazza Collegio Borromeo 9, Pavia | www.collegioborromeo.it | eventi@collegioborromeo.it

More info will come soon

Front. Neuroinform. | doi: 10.3389/fninf.2019.00037

New neuronal model with potential to tackle spinocerebellar ataxias disease


Articolo di E. D’Angelo su “Science”: Il cervelletto diventa sociale!

Courses for PhD Students

  • Fundamentals of Data Analysis,

Dr Thierry Nieus  8, 15 e 22 march 2019 h 11-13
aula A di Fisiologia Umana, in via Forlanini 6, Dip. di Medicina Molecolare

  • Dynamical systems, complexity and consciousness, Dr Cattani 17 e il 31 may  h 10-13 Aula da definirsi.

On BioRxiv the scaffold model of the cerebellar network:

The cerebellum gets social

Egidio D’Angelo

Science  18 Jan 2019:
Vol. 363, Issue 6424, pp. 229
DOI: 10.1126/science.aaw2571


Cereb Cortex. 2019 Jan 7. doi: 10.1093/cercor/bhy322.
I See Your Effort: Force-Related BOLD Effects in an Extended Action Execution-Observation Network Involving the Cerebellum.
Casiraghi L, Alahmadi AAS, Monteverdi A, Palesi F, Castellazzi G, Savini G, Friston K, Gandini Wheeler-Kingshott CAM, D’Angelo E.

Action observation (AO) is crucial for motor planning, imitation learning, and social interaction, but it is not clear whether and how an action execution-observation network (AEON) processes the effort of others engaged in performing actions. In this functional magnetic resonance imaging (fMRI) study, we used a “squeeze ball” task involving different grip forces to investigate whether AEON activation showed similar patterns when executing the task or observing others performing it. Both in action execution, AE (subjects performed the visuomotor task) and action observation, AO (subjects watched a video of the task being performed by someone else), the fMRI signal was detected in cerebral and cerebellar regions. These responses showed various relationships with force mapping onto specific areas of the sensorimotor and cognitive systems. Conjunction analysis of AE and AO was repeated for the “0th” order and linear and nonlinear responses, and revealed multiple AEON nodes remapping the detection of actions, and also effort, of another person onto the observer’s own cerebrocerebellar system. This result implies that the AEON exploits the cerebellum, which is known to process sensorimotor predictions and simulations, performing an internal assessment of forces and integrating information into high-level schemes, providing a crucial substrate for action imitation.

November 2018: disseminations

Siamo lieti di invitarvi al seminario dal titolo:

Neural mechanisms for learning in the gustatory cortex

Prof. Arianna Maffei Arianna Maffei

 Department of Neurobiology & Behavior

Stony Brook University (NY)

Venerdì 16 Novembre 2018

 Ore 15:00, Aula 4 del Nuovo Polo Didattico di Ingegneria

Via Ferrata, Pavia

October 2018: disseminations

Data-driven reconstruction of

a point-neuron mouse brain

Dr. Csaba Erö

 Neurorobotics Section of the Simulation Neuroscience Division of EPFL

École Polytechnique Federale De Lausanne

9 Ottobre 2018

Ore 12:00 

Aula Grande

Istituto di Fisiologia Umana


Information processing in cerebellar modules

Prof. Philippe Isope


Team Leader “Physiology of Neural Networks”

Institut des Neurosciences Cellulaires et Intégratives (INCI)

CNRS UPR 3212, Université de Strasbourg

 12 Ottobre 2018

Ore 15:00

Aula Grande

Istituto di Fisiologia Generale

Via Forlanini 6


School of Brain Cells & Circuits “Camillo Golgi”

Ettore Majorana Foundation and Centre for Scientific Culture, Erice (Italy)


The Neural Bases of Action – from cellular microcircuits to large-scale networks and modelling.

Course Directors: Egidio D’Angelo, Claudia Gandini Wheeler-Kingshott & Sten Grillner

Date: Devember 2018

Application are open: HOW to APPLY

Tweet from HBP education


Casella prize 2018: link to News

Posted in Almo Collegio Borromeo

31-5 Casella Prize 2018 – Chris de Zeeuw

How the cerebellum can help us the way we think

Thursday 31st May 2018, h. 21

Almo Collegio Borromeo

Casella Lecture and Prize 2018

Lectio Magistralis

Chris De Zeeuw (info)

31-5 Casella Prize 2018 – Chris de Zeeuw

Vice-director Netherlands Institute for Neuroscience – Royal Dutch Academy of Arts & Sciences (KNAW), Amsterdam Dept. of Neuroscience of Erasmus MC in Rotterdam

presentation by

Egidio U. D’Angelo


Giovedì 31 maggio, alle 21, l’Almo Collegio Borromeo di Pavia ospiterà un appuntamento scientifico di portata internazionale: il “Casella Prize 2018”, in memoria del professor Cesare Casella, Alunno del Borromeo scomparso nel 2014 già direttore dell’Istituto di Fisiologia dell’Università di Pavia e presidente del Consiglio di Amministrazione del Collegio.

Il Premio 2018 sarà assegnato dal Collegio Borromeo al professor Chris De Zeeuw, vice direttore dell’Istituto Olandese di Neuroscienze, nonché membro della Reale Accademia di Arte e Scienze di Amsterdam e del Dipartimenti di Neuroscienze dell’ “Erasmus MC” di Rotterdam.

Il professor De Zeeuw  terrà una lectio magistralis (in lingua inglese) dal titolo  “How the cerebellum can help us the way we think” ovvero “come il cervelletto può aiutarci nel modo in cui pensiamo”.

La grande novità scientifica proposta nell’intervento dello scienziato olandese, frutto di ricerche in corso da anni, è che il cervelletto, oltre a coordinare i movimenti del nostro corpo, è in grado anche di svolgere una funzione fondamentale nel controllo dei comportamenti cognitivi. Il professor De Zeeuw spiegherà come l’elaborazione delle informazioni (attraverso il ricordo degli eventi passati e la pianificazione di comportamenti futuri) possa svolgersi attraverso il cervelletto, che è sempre stato pensato per essere principalmente coinvolto nel controllo del movimento.

Introdurrà la lectio il professor Egidio D’Angelo, ordinario di Fisiologia al Dipartimento di Scienze del Farmaco dell’Università di Pavia.


The brain can store information in persistent neural activity to remember past events and plan future behavior. Persistent and ramping activity in frontal cortex reflects the anticipation of specific movements. This preparatory activity has long been postulated to emerge from processes distributed across multiple brain regions, but it has remained largely unclear how this activity is mediated by multi-regional interactions and which brain areas are involved. For this lecture, I will describe how a persistent representation of information in the frontal cortex critically depends on cerebellar processing, a brain structure originally thought to be primarily involved in online control of movement. During a sensory discrimination task, in which mice use short-term memory to plan a future directional movement of their tongue, they show persistent ramping activity in both their frontal cortex and cerebellar nuclei, instructing future movements seconds before their onset. Transient perturbations in activity of the medial cerebellar nucleus disrupt these ramping activities as well as their choices to move their tongue in the right direction. Moreover, silencing frontal cortex activity abolishes preparatory activity in the cerebellar nuclei affecting a closed cortico-cerebellar loop. Finally, ongoing motor programs in this closed loop can be altered by manipulating activity in the olivocerebellar system, resetting the planned behavior. Together, these experiments highlight the way the cerebellum can control cognitive behaviors that extend beyond coordination of ongoing movements.

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Nell’ambito della manifestazione:

14-15-16 Maggio 2018 

nella serata di martedì 15 Maggio alle ore 19:00

si terrà un intervento dal titolo:

“Human Brain Project.

Neuroscienze e modelli delle funzioni neurali”

Ulteriori informazioni al seguente link:


Corso di Neuroscienze 2018 presso Almo Collegio Borromeo

Programma: Neuroscienze2018

«Human Brain», il mondo dell’encefalo: nuove cure e sviluppo di moderne tecnologie

A Pavia il meeting di tutte le unità italiane coinvolte nel progetto da 1,2 miliardi di euro finanziato dall’Europa in 10 anni, giunto a metà percorso
Pubblicato il 30/03/2018

Disporre un cervello virtuale su cui testare l’efficacia di nuovi interventi terapeutici o di prevenzione significherebbe accelerare notevolmente la ricerca di una cura per le patologie neurologiche. Simulare il cervello è uno degli obiettivi dello «Human Brain Project» progetto da 1,2 miliardi di euro finanziato dall’Europa in 10 anni e che vede al lavoro 120 laboratori europei, di cui 16 unità italiane…

La stampa: articolo completo


HBP National Outreach Event Italy

13 Marzo 2018, Aula Magna

Università degli Studi di Pavia

Tutte le informazioni relative all’evento sono reperibili al seguente link:


L’evento è aperto al pubblico, è gradita la registrazione all’evento.

Here is the link for


REsearch AnD Innovation Newsletter of the University of Pavia



13nt March 2018

“Human Brain Project: the endeavour of neuroscience”

Venue: Università degli Studi di Pavia; dip. di Scienze del Sistema Nervoso e del Comportamento

The Human Brain Project, the European flagship that has raised interest for the breakthroughing approach to brain investigation, is entering its fourth year of activity. The project aims at generating large-scale models of brain functions and promises big advances in prevention and cure of brain diseases as well as in neuro-informatics and technology. There are several Italian groups involved at various levels in this endeavour. The Italian leaders will present how their activity integrates in vital nodes of Human Brain Project and will update on the general strategies of the project, its achievements and its perspectives.

The preliminary program can be found here: HBP country meeting

For more information contact: hbpcountryitaly@gmail.com

School of Brain Cells & Circuits “Camillo Golgi”

Ettore Majorana Foundation and Centre for Scientific Culture, Erice (Italy)



New: PhD School 2017-2018

Deadline 14th July 2017, 5 PM

Application form


68° Congresso Nazionale SIF


Pavia, 6-8 settembre 2017

Abstract submission:
30 June 2017

Early bird payment:
30 June 2017

Online registration:
31 July 2017

For more information please follow this link: https://sif2017.azuleon.org/


5th Annual Human Brain Project Summit

Scottish Events Campus (SEC), Glasgow, Scotland

Oct. 17, 2017 Open day

Oct. 18, 2017 – Oct. 20, 2017

For more information please follow this link: HBP Summit


International school of brain cells and circuits “Camillo Golgi” 2016

The cerebellum inside-out: cells, circuits and functions

Course Directors: E. D’Angelo, Claudia Gandini Wheeler-Kingshott, Chris De Zeeuw

Date: 1st-5th December 2016

The 2016 Course of the  International School of Brain Cells and Circuits will be dedicated to the cerebellum. See the programme 2016


THE MAIN INTEREST of the laboratory


is on neuronal and synaptic properties involved in computation and learning in the CEREBELLAR NETWORKin particular the following:

    • the mechanisms and functional implications of synaptic transmission and plasticity;
    • the ionic basis of neuronal coding;
    • the spatio-temporal organization of signal processing;
  • cellular neuropathology.    


modello purkinje

Purkinje Cell – Movie (image on the left)

Click on the image to see the whole movie of a Purkinje model!

 (other Video)




EXPIRED PROJECTS LIST)     _____________________________________________________________



Brain Connectivity Center (BCC)


unipv_logoPhD School in Biomedical Sciences (DRSBM) – Coordinated by Prof. Egidido D’Angelo



9th FENS Forum of Neuroscience (Satellite Events) – Jul 2014 


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