Posted in Almo Collegio Borromeo

31-5 Casella Prize 2018 – Chris de Zeeuw

How the cerebellum can help us the way we think

Thursday 31st May 2018, h. 21

Almo Collegio Borromeo

Casella Lecture and Prize 2018

Lectio Magistralis

Chris De Zeeuw (info)

31-5 Casella Prize 2018 – Chris de Zeeuw

Vice-director Netherlands Institute for Neuroscience – Royal Dutch Academy of Arts & Sciences (KNAW), Amsterdam Dept. of Neuroscience of Erasmus MC in Rotterdam

presentation by

Egidio U. D’Angelo


The brain can store information in persistent neural activity to remember past events and plan future behavior. Persistent and ramping activity in frontal cortex reflects the anticipation of specific movements. This preparatory activity has long been postulated to emerge from processes distributed across multiple brain regions, but it has remained largely unclear how this activity is mediated by multi-regional interactions and which brain areas are involved. For this lecture, I will describe how a persistent representation of information in the frontal cortex critically depends on cerebellar processing, a brain structure originally thought to be primarily involved in online control of movement. During a sensory discrimination task, in which mice use short-term memory to plan a future directional movement of their tongue, they show persistent ramping activity in both their frontal cortex and cerebellar nuclei, instructing future movements seconds before their onset. Transient perturbations in activity of the medial cerebellar nucleus disrupt these ramping activities as well as their choices to move their tongue in the right direction. Moreover, silencing frontal cortex activity abolishes preparatory activity in the cerebellar nuclei affecting a closed cortico-cerebellar loop. Finally, ongoing motor programs in this closed loop can be altered by manipulating activity in the olivocerebellar system, resetting the planned behavior. Together, these experiments highlight the way the cerebellum can control cognitive behaviors that extend beyond coordination of ongoing movements.

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Nell’ambito della manifestazione:

14-15-16 Maggio 2018 

nella serata di martedì 15 Maggio alle ore 19:00

si terrà un intervento dal titolo:

“Human Brain Project.

Neuroscienze e modelli delle funzioni neurali”

Ulteriori informazioni al seguente link:’Angelo




Corso di Neuroscienze 2018 presso Almo Collegio Borromeo

Programma: Neuroscienze2018


«Human Brain», il mondo dell’encefalo: nuove cure e sviluppo di moderne tecnologie

A Pavia il meeting di tutte le unità italiane coinvolte nel progetto da 1,2 miliardi di euro finanziato dall’Europa in 10 anni, giunto a metà percorso
Pubblicato il 30/03/2018

Disporre un cervello virtuale su cui testare l’efficacia di nuovi interventi terapeutici o di prevenzione significherebbe accelerare notevolmente la ricerca di una cura per le patologie neurologiche. Simulare il cervello è uno degli obiettivi dello «Human Brain Project» progetto da 1,2 miliardi di euro finanziato dall’Europa in 10 anni e che vede al lavoro 120 laboratori europei, di cui 16 unità italiane…

La stampa: articolo completo


HBP National Outreach Event Italy

13 Marzo 2018, Aula Magna

Università degli Studi di Pavia

Tutte le informazioni relative all’evento sono reperibili al seguente link:


L’evento è aperto al pubblico, è gradita la registrazione all’evento.






Here is the link for


REsearch AnD Innovation Newsletter of the University of Pavia










13nt March 2018

“Human Brain Project: the endeavour of neuroscience”

Venue: Università degli Studi di Pavia; dip. di Scienze del Sistema Nervoso e del Comportamento


The Human Brain Project, the European flagship that has raised interest for the breakthroughing approach to brain investigation, is entering its fourth year of activity. The project aims at generating large-scale models of brain functions and promises big advances in prevention and cure of brain diseases as well as in neuro-informatics and technology. There are several Italian groups involved at various levels in this endeavour. The Italian leaders will present how their activity integrates in vital nodes of Human Brain Project and will update on the general strategies of the project, its achievements and its perspectives.


The preliminary program can be found here: HBP country meeting

For more information contact:



School of Brain Cells & Circuits “Camillo Golgi”

Ettore Majorana Foundation and Centre for Scientific Culture, Erice (Italy)


Programme 2017


New: PhD School 2017-2018

Deadline 14th July 2017, 5 PM

Application form



68° Congresso Nazionale SIF


Pavia, 6-8 settembre 2017

Abstract submission:
30 June 2017

Early bird payment:
30 June 2017

Online registration:
31 July 2017

For more information please follow this link:


5th Annual Human Brain Project Summit

Scottish Events Campus (SEC), Glasgow, Scotland

Oct. 17, 2017 Open day

Oct. 18, 2017 – Oct. 20, 2017

For more information please follow this link: HBP Summit


International school of brain cells and circuits “Camillo Golgi” 2016

The cerebellum inside-out: cells, circuits and functions

Course Directors: E. D’Angelo, Claudia Gandini Wheeler-Kingshott, Chris De Zeeuw

Date: 1st-5th December 2016

The 2016 Course of the  International School of Brain Cells and Circuits will be dedicated to the cerebellum. See the programme 2016


THE MAIN INTEREST of the laboratory


is on neuronal and synaptic properties involved in computation and learning in the CEREBELLAR NETWORKin particular the following:

  • the mechanisms and functional implications of synaptic transmission and plasticity;
  • the ionic basis of neuronal coding;
  • the spatio-temporal organization of signal processing;
  • cellular neuropathology.    


modello purkinje

Purkinje Cell – Movie (image on the left)

Click on the image to see the whole movie of a Purkinje model!


 (other Video)




EXPIRED PROJECTS LIST)     _____________________________________________________________





Brain Connectivity Center (BCC)


unipv_logoPhD School in Biomedical Sciences (DRSBM) – Coordinated by Prof. Egidido D’Angelo


9th FENS Forum of Neuroscience (Satellite Events) – Jul 2014 



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