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This meeting is supported by the Italian Ministry of Health:
GR-2009-143804 to Sergio Solinas
RF-2009-1475845 to Egidio D’Angelo

Biologically-based models
of neurons and microcircuits

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TOPIC:

Neuronal and microcircuit models are getting more and more popularity as tools for investigating brain functions. In particular, biologically-based models help explaining how ionic conductance generate the excitable response of complex neuronal structures. On one side, modeling can extend at the level of molecular interactions in the membrane and cytoplasm. On the other side, neuronal models can be coupled through synapses extending into the level of microcircuits. It is now time to make the point on the methodologies and strategies and on the achievements obtained at the different modeling levels.

This satellite is timely, as it occurs in close relationship with the launch of the Human Brain Project (HBP), which will make massive use of biologically-based models in multi-scale simulations.

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The speakers will present the following issues:

    • molecular modeling of intracellular and membrane mechanisms
    • neuronal models of neurons in different brain regions
    • synaptic models and synaptic dynamics
    • microcircuit models (including cerebral cortex, cerebellum, hippocampus, basal ganglia)
    • strategies for neuronal and microcircuit modeling
    • model reduction for large-scale simulations
    • multi-scale modeling
    • closed-loop simulations